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Therapeutics
A lifestyle intervention or metformin prevented or delayed the onset of metabolic syndrome in persons at risk

https://doi.org/10.1136/ebm.10.6.172

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    Orchard TJ, Temprosa M, Goldberg R, et al. The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Ann Intern Med 2005;142:611–9.
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 Q In persons with impaired glucose tolerance, does an intensive lifestyle intervention (ILS) or treatment with metformin plus standard lifestyle recommendations prevent onset or promote resolution of metabolic syndrome?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★☆☆☆

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial (The Diabetes Prevention Program randomised trial).

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded (clinicians, participants, data collectors, and outcome assessors for metformin and placebo).*

    Embedded ImageFollow-up period:

    mean 3.2 years.

    Embedded ImageSetting:

    27 centres in the US.

    Embedded ImageParticipants:

    3234 participants ⩾25 years of age (mean age 51y, 68% women) without diabetes who had a body mass index ⩾24 kg/m2 (⩾22 kg/m2 for Asian Americans) and a plasma glucose concentration 5.3–7.0 mmol/l (95–125 mg/dl) (⩽7.0 mmol/l [⩽125 mg/dl] for Native Americans) …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Diabetes Prevention Program Coordinating Center, George Washington University, Rockville, MD, USA

    • Source of funding: National Institutes of Health.